Friday (April 28) – Invited Experts
(I) Jeremy Draghi
- Essential Reading
- Draghi, J.A., and M.C. Whitlock. 2015. Overdominance interacts with linkage to determine the rate of adaptation to a new optimum. Journal of Evolutionary Biology 28:95–104.
- Draghi, J.A., T.L. Parsons, G.P. Wagner, and J.B. Plotkin. 2010. Mutational robustness can facilitate adaptation. Nature 463:353–355.
- Background Papers
- Whitlock, M.C. 1996. The red queen beats the jack-of-all trades: limitations on the evolution of phenotypic plasticity and niche breadth. The American Naturalist 148:S65–S77.
- Stiffler, M.A., D.R. Hekstra, and R. Ranganathan. 2015. Evolvability as a function of purifying selection in TEM-1 β-lactamase. Cell 160:882–892.
(II) Elena Alvarez-Buylla
- Essential Reading
- Álvarez-Buylla, E.R., Á. Chaos, M. Aldana, M. Benítez, Y. Cortes-Poza, C. Espinosa-Soto, D.A. Hartasánchez2,3, R.B. Lotto, D. Malkin, G.J. Escalera Santos, and P. Padilla-Longoria. 2008. Floral morphogenesis: stochastic explorations of a gene network epigenetic landscape. PLoS ONE 3(11):e3626.
- Barrio, R.Á., A. Hernández-Machado, C. Varea, J.R. Romero-Arias, and E.R. Álvarez-Buylla (2010) Flower development as an interplay between dynamical physical fields and genetic networks. PLoS ONE 5(10): e13523.
- Background Papers
- Villarreal, C., P. Padilla-Longoria, and E.R. Álvarez-Buylla. 2012. General theory of genotype to phenotype mapping: derivation of epigenetic landscapes from N-node complex gene regulatory networks. Physical Review Letters 109:118102.
- Álvarez-Buylla, E.R., J. Dávila-Velderrain, and J.C. Martínez-García. 2016. Systems biology approaches to development beyond bioinformatics: nonlinear mechanistic models using plant systems. BioScience 66:371–383.
(III) Joanna Masel
- Essential Reading
- Masel, J. and M.V. Trotter. 2010. Robustness and evolvability. Trends in Genetics 26:406–414.
- Rajon, E. and J. Masel. 2011. Evolution of molecular error rates and the consequences for evolvability. Proceedings of the National Academy of Sciences USA 8:286–292.
- Background Papers
- Wilson, B.A., S.G. Foy, R. Neme, and J. Masel. 2017. Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth. Nature Ecology & Evolution 1:0146.
- Bertram, J., K. Gomez, and J. Masel. 2017. Predicting patterns of long-term adaptation and extinction with population genetics. Evolution 71:204–214.
(IV) David Houle
- Essential Reading
- Hansen, T.F., and D. Houle. 2008. Measuring and comparing evolvability and constraint in multivariate characters. Journal of Evolutionary Biology 21:1201–1219.
- Hansen, T.F., C. Pelabon, and D. Houle. 2011. Heritability is not evolvability. Evolutionary Biology 38:258–277.
- Background Papers
- Wagner, G.P., and L. Altenberg. 1996. Perspective: complex adaptations and the evolution of evolvability. Evolution 50:967-976.
- Houle, D., B. Morikawa, and M. Lynch. 1996. Comparing mutational variabilities. Genetics 143:1467-1483.
Saturday (April 28) – Topics and Themes
(1) Brett Calcott – Engineering and Information
- Background Papers
- Calcott, B. 2014a. Engineering and evolvability. Biology & Philosophy 29:293–313.
- Calcott, B. 2014b. The creation and reuse of information in gene regulatory networks. Philosophy of Science 81: 879–90.
- Dubuis, J.O., G. Tkačik, E.F. Wieschaus, T. Gregor, and W. Bialek. 2013. Positional information in bits. Proceedings of the National Academy of Sciences USA 110:16301–8.
(2) Michael Travisano – Experimental Evolution
- Background Papers
- Díaz Arenas, C., and T.F. Cooper. 2013. Mechanisms and selection of evolvability: experimental evidence. FEMS Microbiology Reviews 37:572–582.
- Libby, E., W.C. Ratcliff, M. Travisano, and B. Kerr. 2014. Geometry shapes evolution of early multicellularity. PLoS Computational Biology 10:e1003803.
- Ratcliff, W.C., J.D. Fankhauser, D.W. Rogers, D. Greig, and M. Travisano. 2015. Origins of multicellular evolvability in snowflake yeast. Nature Communications 6:6102.
(3) Robustness, Criticality, Modularity
- Background Papers
- Esteve-Altava, B., R. Diogo, C. Smith, J.C. Boughner, and D. Rasskin-Gutman. 2015. Anatomical networks reveal the musculoskeletal modularity of the human head. Scientific Reports 5:8298.
- Felix, M.-A., and M. Barkoulas. 2015. Pervasive robustness in biological systems. Nature Reviews Genetics 16:483-496.
- Friedlander, T., A.E. Mayo, T. Tlusty, and U. Alon. 2013. Mutation rules and the evolution of sparseness and modularity in biological systems. PLoS ONE 8:e70444.
- Torres-Sosa, C., S. Huang, and M. Aldana. 2012. Criticality is an emergent property of genetic networks that exhibit evolvability. PLoS Computational Biology 8:e1002669.
- Wagner, A. 2012. The role of robustness in phenotypic adaptation and innovation. Proceedings of the Royal Society B: Biological Sciences 279:1249–1258.
(4) Networks and Proteins
- Background Papers
- Garfield, D.A., D.E. Runcie, C.C. Babbitt, R. Haygood, W.J. Nielsen, and G.A. Wray. 2013. The impact of gene expression variation on the robustness and evolvability of a developmental gene regulatory network. PLoS Biology 11:e1001696.
- Jiménez, A. J. Cotterell, A. Munteanu, and J. Sharpe. 2015. Dynamics of gene circuits shapes evolvability. Proceedings of the National Academy of Sciences USA 112:2103–2108.
- Landry, C.R., B. Lemos, S.A. Rifkin, W.J. Dickinson, and D.L. Hartl. 2007. Genetic properties influencing the evolvability of gene expression. Science 317:118–121.
- Niklas, K.J., S.E. Bondos, A.K. Dunker, and S.A. Newman. 2015. Rethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modifications. Frontiers in Cell and Developmental Biology 3:8.
- Payne, J.L., and A. Wagner. 2014. The robustness and evolvability of transcription factor binding sites. Science 343:875–877.
- Yanagida, H., A. Gispan, N. Kadouri, S. Rozen, M. Sharon, N. Barkai, and D.S. Tawfik. 2015. The evolutionary potential of phenotypic mutations. PLoS Genetics 11: e1005445.
(5) Paleobiology – History of Life
- Background Papers
- Chirat, R., D.E. Moulton, and A. Goriely. 2013. Mechanical basis of morphogenesis and convergent evolution of spiny seashells. Proceedings of the National Academy of Sciences USA 110:6015–6020.
- Erwin, D.H. 2008. Macroevolution of ecosystem engineering, niche construction and diversity. Trends in Ecology & Evolution 23:304–310.
- Herringshaw, L.G., R.H.T. Callow, and D. McIlroy. 2017. Engineering the Cambrian explosion: the earliest bioturbators as ecosystem engineers. In: Brasier, A.T., D. McIlroy, and N. McLoughlin (eds) Earth System Evolution and Early Life. Geological Society, London, Special Publications, 448.18.
- Jablonski, D. 1987. Heritability at the species level: analysis of geographic ranges of Cretaceous mollusks. Science 238:360–363.
- Young, N.M., G.P. Wagner, and B. Hallgrímsson. 2010. Development and the evolvability of human limbs. Proceedings of the National Academy of Sciences USA 107:3400–3405.
Sunday (April 30) – Conceptual Reflections
(1) Conceptual Issues: Extrinsicality
- Background Papers
- Love, A.C. 2003. Evolvability, dispositions, and intrinsicality. Philosophy of Science 70:1015-1027.
- Cantalapiedra, J.L., J.L. Prado, M. Hernández Fernández, and M.T. Alberdi. 2017. Decoupled ecomorphological evolution and diversification in Neogene-Quaternary horses. Science 355:627-630.
- Zaman, L., J.R. Meyer, S. Devangam, D.M. Bryson, R.E. Lenski, and C. Ofria. 2014. Coevolution drives the emergence of complex traits and promotes evolvability. PLoS Biology 12:e1002023.
(2) The Meaning of Evolvability
- Background Paper
- Brookfield, J.F.Y. 2009. Evolution and evolvability: celebrating Darwin 200. Biology Letters 5:44–46.
- Brown, R.L. 2014. What evolvability really is. The British Journal for the Philosophy of Science 65:549–572.
- Pigliucci, M. 2008. Is evolvability evolvable? Nature Reviews Genetics 9:75–82.
- Wimsatt, W.C. 2013. Evolution and the stability of functional architectures. In P. Huneman (ed.), Functions: Selection and Mechanisms. New York: Springer, 19–41.
- General Background Papers
- Kirschner, M., and J. Gerhart. 1998. Evolvability. Proceedings of the National Academy of Sciences USA 95:8420–8427.
- Huynen, M.A., P.F. Stadler, and W. Fontana. 1996. Smoothness within ruggedness: the role of neutrality in adaptation. Proceedings of the National Academy of Sciences USA 93:397–401.
- Livnat, A., C. Papadimitriou, J. Dushoff, and M.W. Feldman. 2008. A mixability theory for the role of sex in evolution. Proceedings of the National Academy of Sciences USA 105:19803–19808.
- Prud’homme, B., N. Gompel, and S.B. Carroll. 2007. Emerging principles of regulatory evolution. Proceedings of the National Academy of Sciences USA 104:8605–12.
- Wagner, G., and J. Zhang. 2011. The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. Nature Reviews Genetics 12:204–213.
- Yampolsky, L.Y. and A. Stoltzfus. 2001. Bias in the introduction of variation as an orienting factor in evolution. Evolution & Development 3:73–83.